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Reassortment of Thogoto Virus (a Tick-borne Influenza-like Virus) in a Vertebrate Host

Natural Environment Research Council, Institute of Virology, Mansfield Road, Oxford OX1 3SR, U.K.

Reassortment is an important factor in the evolution of segmented genome viruses. For arthropod-borne viruses it is important to determine whether the vertebrate host acts as a site of reassortant virus formation since vertebrates often act as amplifying hosts. Mutants of Thogoto virus, a tick-borne orthomyxo-like virus, were shown to produce wild-type progeny in a dually infected permissive host (hamster), when hamsters were infected with two mutant viruses either by direct inoculation or by oral transmission from infected ticks. Viral dose and time of co-infection of the host affected the incidence of reassortment. This is the first report of reassortment of an arbovirus following infection of a vertebrate host via an arthropod vector.

Keywords: Thogoto virus, arbovirus, reassortment in vivo

Received 24 November 1986; accepted 2 February 1987.