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Virulence Is not Conserved in Recombinants between Herpes Simplex Virus Types 1 and 2

¹ MRC Herpesvirus Research Group, Department of Microbiology, University of Leeds, Leeds LS2 9JT
and² National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K.

The virulence of 31 herpes simplex virus type 1 x herpes simplex virus type 2 intertypic recombinants was determined following intraperitoneal inoculation into CBA mice. Only eight of the recombinants killed any of the mice and of these, only one recombinant was as virulent as its type 2 parent, the other seven recombinants being intermediate between their type 1 and type 2 parental viruses in virulence. These results indicate that most heterotypic combinations are attenuated independently of the virulence of the parental viruses and therefore that the virulence of HSV is controlled multigenically.

Keywords: HSV, intertypic recombinants, virulence

Received 22 October 1986; accepted 16 February 1987.

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