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Sequence Analysis of the Matrix Protein Gene of Human Parainfluenza Virus Type 3: Extensive Sequence Homology among Paramyxoviruses

¹ Laboratory of Infectious Diseases, Building 7, Room 100, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
and² Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, U.S.A.

The sequences of the human parainfluenza virus type 3 (PIV3) matrix (M) mRNA [1150 nucleotides exclusive of poly(A)] and predicted M protein (353 amino acids) were determined by sequence analysis of cloned cDNA and viral genomic RNA. The geneend sequence of the M gene differed from the semi-conserved gene-end sequence of the other PIV3 genes by an apparent insertion of eight nucleotides. The PIV3 M protein shared high sequence homology with Sendai virus and moderate homology with measles virus and canine distemper virus. Statistical analysis of the available sequences showed that the M protein was the most highly conserved parainfluenza viral protein.

Keywords: sequence analysis, matrix protein, paramyxovirus evolution

Received 12 January 1987; accepted 10 February 1987.