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The Products of Gene U_S11 of Herpes Simplex Virus Type 1 Are DNA-binding and Localize to the Nucleoli of Infected Cells

MRC Virology Unit, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

We have used antisera raised against synthetic oligopeptides to characterize the protein products from herpes simplex virus type 1 gene U_S11. These antisera recognized predominantly polypeptides of apparent molecular weight 21000 and 22000, but also polypeptides of apparent molecular weight 17500, 15000, 14000 and 11000. Tryptic peptide fingerprint analysis confirmed that these polypeptides were all closely related. The 21000 and 22000 molecular weight polypeptides were shown to be DNA-binding proteins, and immune electron microscopy demonstrated their strong localization within nucleoli of infected cells.

Keywords: HSV-1, DNA-binding protein, nucleolus

Received 4 December 1986; accepted 24 March 1987.

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