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Immune Response to Rotavirus Polypeptides after Vaccination with Heterologous Rotavirus Vaccines (RIT 4237, RRV-1)

¹ Department of Virology, National Bacteriological Laboratory, S-105 21 Stockholm
² Department of Virology, Karolinska Institute, School of Medicine, S-105 21 Stockholm, Sweden
³ Department of Clinical Sciences, University of Tampere, SF-335 20 Tampere, Finland
and⁴ Department of Virology, University of Umeå, S-901 85 Umeå, Sweden

The antibody response to individual rotavirus polypeptides after vaccination with live attenuated heterologous rotavirus vaccines was studied with a radioimmunoprecipitation assay (RIPA). Following vaccination with bovine rotavirus strain RIT 4237 and rhesus monkey rotavirus strain RRV-1, an antibody response was demonstrated mainly against the inner capsid polypeptides VP2 and VP6 and to a lesser extent against VP3/VP4. There was no qualitative difference between the vaccines in the antibody response; both vaccines induced antibodies against the same polypeptides. Quantitatively the antibody response to RRV-1 was somewhat stronger. All prevaccination sera contained by RIPA low levels of rotavirus antibodies. The effect of these antibodies on the ‘take’ of the vaccines is discussed.

Keywords: rotavirus, vaccine, immune response

Received 29 December 1986; accepted 30 March 1987.

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