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J Gen Virol 68 (1987), 2039-2041; DOI 10.1099/0022-1317-68-7-2039
© 1987 Society for General Microbiology
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Inhibitory Effect of a Protease Inhibitor, Leupeptin, on the Development of Influenza Pneumonia, Mediated by Concomitant Bacteria

Masato Tashiro2, Hans-Dieter Klenk3 and Rudolf Rott1

1 Institut für Virologie, Justus-Liebig-Universität Giessen, Frankfurter Strasse 107, D-6300 Giessen, F.R.G.
2 Department of Bacteriology, Yamagata University School of Medicine, Zao-Iida, Yamagata 990-23, Japan
and3 Institut für Virologie, Philipps-Universität Marburg, D-3550 Marburg, F.R.G.

The protease inhibitor leupeptin prevented multiple step replication of an influenza virus (A/swine/1976/31, H1N1) mediated by staphylococcal proteases. It also suppressed virus replication and development of fatal pneumonia in mice co-infected with the virus and Staphylococcus aureus.

Keywords: influenza, leupeptin, S. aureus

Received 6 March 1987; accepted 14 April 1987.


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Copyright © 1987 by the Society for General Microbiology.