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Genome Variations in Herpes Simplex Virus Type 2 Strains Isolated in Japan and Sweden

¹ Department of Oral Bacteriology, School of Dentistry, Hokkaido University, N-13 W-7, Kita-Ku, Sapporo 060
² Department of Obstetrics and Gynaecology, School of Medicine, University of Tokyo, Tokyo 113, Japan
³ Department of Clinical Microbiology, Karolinska Hospital, 104 01 Stockholm, Sweden
and⁴ Department of Molecular Biology, Cancer Research Institute, Sapporo Medical College, Sapporo 060, Japan

One-hundred and twenty-three epidemiologically unrelated strains of herpes simplex virus type 2 (HSV-2) isolated in Japan and Sweden (68 Japanese and 55 Swedish isolates) were compared by analysis of their genomes using five restriction endonucleases: BamHI, KpnI, EcoRI, HindIII and BglII. Seven of the 93 restriction sites examined showed statistically significant variation between isolates from the two countries. However, HSV-2 isolates were less variable than the HSV-1 isolates previously analysed from the same countries. Using 12 restriction sites as markers, the HSV-2 isolates were classified into 41 cleavage patterns; 17 were specific for Japanese isolates and 15 were specific for Swedish isolates. Correlation coefficients between some sets of 12 markers were significant, but significant correlations between Japanese and Swedish isolates were distinct for each country. Both Japanese and Swedish isolates were assigned to three major patterns with no significant difference in incidence. In contrast, in two other major patterns, differences in incidence between the isolates were statistically significant. These results suggest that HSV-2 populations in geographically separated countries have distinct cleavage site distributions.

Keywords: HSV-2, cleavage patterns, genome structure

Received 17 November 1986; accepted 21 April 1987.

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