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1 National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K.
and2 Department of Microbiology, University of Alabama, Birmingham, Alabama 35294, U.S.A.
We examined the specificity of BALB/c cytotoxic T (Tc) cells for respiratory syncytial virus (RSV) components, using recombinant vaccinia viruses (VV) coding for several individual RSV proteins. We found that immunization with the different VVs yielded the following Tc memory cell populations: high levels of RSV-specific Tc cells were induced with the fusion protein VV, but low levels were induced with VV, coding for the RSV nucleoprotein. Tc cell recognition of attachment glycoprotein, part of the matrix molecule or 1A internal protein was poor. While high levels of fusion protein-specific Tc cells were induced by the fusion protein VV, they showed poor cross-reactivity between the A2 and 8/60 RSV strains compared with Tc cells primed by RSV infection.
Keywords: RSV, cytotoxic T cells, vaccinia virus
Received 26 March 1987;
accepted 7 May 1987.
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