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Lack of Correlation between Serum Titres of Interferon ,, Natural Killer Cell Activity and Clinical Susceptibility in Mice Infected with Two Isolates of Lymphocytic Choriomeningitis Virus

D. C. Pevear^3,

¹ Institut für Pathologie, Universitätsspital, 8091 Zürich, Switzerland
² Institut für Immunologie und Virologie, Universität Zürich, 8006 Zürich, Switzerland
and³ Department of Biology, Rensselaer Polytechnic Institute, Troy, New York, U.S.A.

Intracerebral infection of adult immunocompetent mice with most strains of lymphocytic choriomeningitis virus (LCMV) caused a systemic infection and led to severe meningoencephalitis and death due to the induced T cell immune response. The susceptibility of congenic mice to the two plaque variants Docile and Aggressive of LCMV strain UBC was shown to be mouse strain-dependent. To investigate the possible correlation between acid-stable interferon (IFN) and natural killer (NK) cell responses and the susceptibility to the two UBCLCMV substrains, serum titres of acid-stable antiviral activity, presumably IFN-, and NK cell activities were determined in various mouse strains at different times after intracerebral infection. The two viral isolates induced comparable IFN-, serum titres and caused similar NK activities in the same mouse strain. Between different mouse strains, marked differences in the kinetics and amount of IFN production were observed, yet there was no correlation with the susceptibility to the two UBC LCMV substrains. Additionally, there was no correlation between the magnitude of the IFN-, serum titres and the NK activities induced in the spleen by the viral inocula. Overall, the findings suggest that levels of circulating IFN-, are only of minor importance for the development of LCM disease.

Keywords: LCMV, IFN, NK activity, clinical susceptibility

Present address: Department of Neurology, Northwestern University Medical School, Chicago, Illinois, U.S.A.

Received 2 December 1986; accepted 27 April 1987.

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