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J Gen Virol 68 (1987), 2219-2222; DOI 10.1099/0022-1317-68-8-2219
© 1987 Society for General Microbiology
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Natural Killer Cells Are Not Required for Interferon-mediated Prophylaxis Against Vaccinia or Murine Cytomegalovirus Infections

Jack F. Bukowski, Kim W. McIntyre, Hyekyung Yang and Raymond M. Welsh

Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, U.S.A.

Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic:polycytidylic acid (polyI:polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, polyI:polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.

Keywords: interferon (MuIFN-beta), vaccinia virus, cytomegalovirus, murine

Received 10 March 1987; accepted 22 May 1987.


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