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Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305, U.S.A.
We have defined the boundaries of the a sequence from human cytomegalovirus (CMV) strain Towne, characterized internal variability and determined the position of the cleavage site used to generate genomic termini. The cleavage site is positioned a fixed distance from two stretches of sequence homology that have been observed near the ends of many herpesvirus genomes. Unlike a comparable region in CMV (AD169), the CMV (Towne) a sequence has a relatively low level of variability within the a sequence and its structure is stable through repeated virus passage.
Keywords: CMV, herpesvirus a sequence, site-specific inversion
Received 20 February 1987;
accepted 21 April 1987.
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