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J Gen Virol 68 (1987), 2245-2247; DOI 10.1099/0022-1317-68-8-2245
© 1987 Society for General Microbiology
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High Genetic Stability of the Region Coding for the Structural Proteins of Yellow Fever Virus Strain 17D

Philippe Desprès, Annie Cahour, Alfred Dupuy1, Vincent Deubel1,{dagger}, Michèle Bouloy, Jean Pierre Digoutte1 and Marc Girard

Unité de Virologie Moléculaire, UA CNRS 545, Institut Pasteur, 75724 Paris Cedex 15, France
and1 Institut Pasteur, B.P. 220, Dakar, Sénégal

The genome of the Pasteur 17D-204 vaccine strain of yellow fever virus has been cloned into pBR327. The inserts of recombinant plasmids were analysed by restriction cleavage pattern and compared with that of the genome of another substrain previously cloned and sequenced. Ten of the overlapping inserts were found to contain the sequence of the complete genome. We have sequenced approximately 3680 bases of the 5' region which codes for the C, M and E structural proteins and the NS1 non-structural protein. This sequence is the same as that reported previously, indicating a remarkable stability of these two vaccine substrains.

Keywords: YFV, genetic stability, structural proteins

{dagger} Present address: Centers for Disease Control, Fort Collins, Colorado 80522, U.S.A.

Received 3 March 1987; accepted 28 April 1987.


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