HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hamsíková, E. Articles by Vonka, V. Search for Related Content PubMed PubMed Citation Articles by Hamsíková, E. Articles by Vonka, V. Agricola Articles by Hamsíková, E. Articles by Vonka, V.

Immunogenicity of a Synthetic Peptide Corresponding to a Portion of the Heavy Chain of H3N2 Influenza Virus Haemagglutinin

E. Hamíková¹

J. Jeek²

¹ Department of Experimental Virology, Institute of Sera and Vaccines, Prague
and² Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

Rabbits were immunized with a synthetic octadecapeptide corresponding to the sequence ser-91 to leu-108 of the haemagglutinin heavy chain of H3N2 influenza A viruses. They developed antibodies reactive in solid-phase radioimmunoassay (SPRIA) with the peptide and with haemagglutinins of various H3N2 viruses but not of heterotypic H1N1 and H2N2 viruses. The antibodies were also non-reactive in the haemagglutination-inhibition or neutralization test. Influenza H3N2 virus replicated in the lungs of mice immunized with the peptide to the same extent as in the control mice. Of 27 human sera possessing anti-H3N2 activity or seven sera from rabbits immunized with either virions or haemagglutinins of various influenza A viruses, none was reactive with the peptide in SPRIA.

Keywords: influenza A virus, synthetic peptide, immunogenicity

Received 27 November 1986; accepted 21 April 1987.

This article has been cited by other articles:

				J Meier, C Meunier-Durmort, C Forest, A Triller, and C Vannier Formation of glycine receptor clusters and their accumulation at synapses J. Cell Sci., January 8, 2000; 113(15): 2783 - 2795. [Abstract] [PDF]