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1 Cancer Research Institute
2 Animal Care Facility
and3 Department of Medicine, University of California, School of Medicine, San Francisco, California 94143-0128, U.S.A.
Several species of small animals were inoculated at birth or as adults with blood components from patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders, or with the human immunodeficiency virus (HIV). No ill effects were noted in rats, hamsters, guinea-pigs, rabbits or musk shrews. Mice inoculated with clinical specimens had a significant incidence of mortality as compared with control groups (18.7% against 5.9%, P < 0.025). Mice receiving HIV showed an increase in mortality, but it was not statistically significant. Infection of the animals by HIV could not be detected by virological or immunological studies. We concluded that none of these animal species provided a useful model for evaluating HIV infection.
Keywords: HIV, infection, small animals
Present address: Department of Laboratory Medicine, University of California, Room 277, Building 100, San Francisco General Hospital, San Francisco, California 94110, U.S.A.
Present address: University of California, School of Medicine, Davis, California 95616, U.S.A.
Received 16 October 1986;
accepted 13 May 1987.
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