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Abnormal Forms of the Herpes Simplex Virus Immediate Early Polypeptide Vmw175 Induce the Cellular Stress Response

Medical Research Council Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, U.K.

Induction of the major stress response in chick embryo fibroblasts, which follows infection at 38.5 °C with the herpes simplex virus mutant tsK, was investigated. Synthesis of cellular stress proteins occurred only when the mutant form of an immediate early polypeptide, Vmw175, was overproduced. Infection with mutant in1411, which has an amber (TAG) termination signal inserted between codons 83 and 84 of the gene encoding Vmw175 and therefore specifies a truncated portion of the polypeptide, failed to stimulate stress protein synthesis. The results suggested that the presence of abnormal forms of Vmw175 at high concentrations was the signal for induction of the stress response in tsK-infected cells.

Keywords: HSV, stress response, immediate early polypeptide

Received 9 March 1987; accepted 19 May 1987.

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