HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yirrell, D. L. Articles by Hill, T. J. Search for Related Content PubMed PubMed Citation Articles by Yirrell, D. L. Articles by Hill, T. J. Agricola Articles by Yirrell, D. L. Articles by Hill, T. J.

The Influence of Androgens on Paralysis in Mice Following Intravenous Inoculation of Herpes Simplex Virus

Department of Microbiology, Medical School, University Walk, Bristol BS8 1TD, U.K.

In mice, intravenous inoculation of relatively avirulent strains of herpes simplex virus [e.g. P₂C₆, a mutant of strain CL(101), deficient in thymidine kinase] produced infection in the adrenal gland and mid-spinal cord followed by hind limb paralysis without death. Male mice were less susceptible to paralysis than female mice. Castration of male mice before inoculation increased their susceptibility to that of female animals; treatment with testosterone reversed this change. The differences in susceptibility to paralysis in the various categories of animal were not reflected in differences in growth of virus in the adrenal gland or spinal cord.

Keywords: HSV-1, paralysis, androgens

Received 27 February 1987; accepted 27 May 1987.

This article has been cited by other articles:

				J. S. Burgos, C. Ramirez, I. Sastre, J. M. Alfaro, and F. Valdivieso Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender J. Virol., February 1, 2005; 79(3): 1605 - 1612. [Abstract] [Full Text] [PDF]

				X. Han, P. Lundberg, B. Tanamachi, H. Openshaw, J. Longmate, and E. Cantin Gender Influences Herpes Simplex Virus Type 1 Infection in Normal and Gamma Interferon-Mutant Mice J. Virol., March 15, 2001; 75(6): 3048 - 3052. [Abstract] [Full Text]