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J Gen Virol 68 (1987), 2521-2524; DOI 10.1099/0022-1317-68-9-2521
© 1987 Society for General Microbiology

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Demonstration that Glycoprotein G Is the Attachment Protein of Respiratory Syncytial Virus

S. Levine1, R. Klaiber-Franco1 and P. R. Paradiso2

1 Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201
and2 Praxis Biologics, 300 East River Road, Rochester, New York 14623, U.S.A.

Two monospecific rabbit antisera to the G glycoprotein, one induced with purified G and the second with a recombinant vaccinia virus containing the gene for G, inhibit the attachment of purified [35S]methionine-labelled Long strain of respiratory syncytial virus to monolayers of HeLa cells. Attachment was not inhibited by monospecific rabbit antisera to glycoprotein F induced with either purified F or with a recombinant vaccinia virus containing the gene for F.

Keywords: RSV, attachment protein, glycoprotein G

Received 25 March 1987; accepted 20 May 1987.


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