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1 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Maryland 20892
and2 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 27232, U.S.A.
Two major antigenic subgroups (A and B) have been described for human respiratory syncytial virus. The complete nucleotide sequence was determined for the fusion (F) mRNA of the subgroup B strain 18537 and the amino acid sequence of the F protein deduced, for comparison with the previously described sequences for the A2 strain of subgroup A. The F proteins (excluding the cleaved signal peptide) were 91% identical between the subgroups, consistent with the previously described high degree of antigenic relatedness. The greatest divergence occurred within the F2 subunit immediately preceding the cleavage activation site.
Keywords: RSV, human, fusion glycoproteins, sequence conservation
Received 14 March 1988;
accepted 30 June 1988.
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