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J Gen Virol 69 (1988), 2901-2906; DOI 10.1099/0022-1317-69-11-2901
© 1988 Society for General Microbiology
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The A and B Subgroups of Human Respiratory Syncytial Virus: Comparison of Intergenic and Gene-overlap Sequences

Philip R. Johnson1,2, and Peter L. Collins1

1 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Building 7, Room 100, National Institutes of Health, Bethesda, Maryland 20892
and2 Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, U.S.A.

Intergenic and flanking gene regions for the 1C-1B, 1B-N, N-P, M-1A, G-F and F-22K gene junctions of respiratory syncytial virus strain 18537, representing antigenic subgroup B, were determined by dideoxynucleotide sequencing of polycistronic cDNAs and mRNAs. Comparison with their counterparts from the subgroup A strain A2 showed that the intergenic sequences were not conserved within or between the strains. Flanking non-coding gene sequences also were generally not conserved except for the highly conserved gene-start and gene-end transcription signals. The sequence of the overlap between the 22K and L genes was conserved almost exactly between the two subgroups.

Keywords: RSV, nucleotide sequence, intergenic sequences

Received 25 January 1988; accepted 13 July 1988.


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