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Effect of Interferon-, Interferon- and Tumour Necrosis Factor on African Swine Fever Virus Replication in Porcine Monocytes and Macrophages

Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Canto Blanco, 28049 Madrid, Spain

Bovine interferon-₁1 (IFN-₁1) and porcine interferon- (IFN-) inhibited African swine fever virus replication in both porcine monocytes and alveolar macrophages. The most potent antiviral activity was observed with IFN--treated alveolar macrophages. The production of both a virulent (CC83) and a non-virulent (BA71) isolate of the virus was inhibited. Bovine tumour necrosis factor did not show antiviral activity in either monocytes or alveolar macrophages. Rather, an increase of African swine fever virus production in tumour necrosis factor -treated monocytes was found. An analysis of viral protein synthesis in IFN-₁l- and IFN--treated alveolar macrophages showed an inhibition of synthesis of some viral proteins. The inhibition of late proteins was very pronounced in IFN--treated cells, and it was probably a consequence of the inhibition of African swine fever virus DNA polymerase activity.

Keywords: African swine fever virus, interferon (BoIFN-; PoIFN-), tumour necrosis factor

Received 15 April 1988; accepted 30 August 1988.

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