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J Gen Virol 69 (1988), 3107-3112; DOI 10.1099/0022-1317-69-12-3107
© 1988 Society for General Microbiology
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Interferon Inhibits Herpes Simplex Virus-specific Translation: a Reinvestigation

B. Altinkilic and G. Brandner

Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene der Universität, D-7800 Freiburg, F.R.G.

Reports on the arrest of herpes simplex virus type 1 (HSV-1) replication by interferon (IFN) are inconsistent. By the use of immunofluorescence and immunoblot assays with monoclonal and polyclonal antibodies, effective arrest of viral translation by human IFN-{alpha} in human fibroblasts was detected for the HSV-1 strains KOS and McIntyre. In HeLa cells which are less sensitive to IFN inhibition and in 444 cells, a HeLa-fibroblast hybrid cell line, the inhibition was less pronounced. These results confirm earlier observations that IFN or polyinosinic-polycytidylic acid block the replication of HSV-1 in human, monkey and mouse cells no later than the immediate early phase of infection.

Keywords: interferon (HuIFN), HSV-1, translation

Received 16 December 1987; accepted 30 August 1988.


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