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Morphological Transformation by Early Region Human Polyomavirus BK DNA of Human Fibroblasts with Deletions in the Short Arm of One Chromosome 11

¹ Department of Virology
² Institute of Human Genetics
and³ Interuniversity Ophthalmology Institute, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative ‘transformation suppressor’ locus situated within the deleted region on the short arm of chromosome 11.

Keywords: BK virus, transformation, human chromosome 11

Received 26 October 1987; accepted 5 November 1987.