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Detection of Aleutian Disease Virus DNA in Tissues of Naturally Infected Mink

Institute of Virology, Hannover Veterinary School, Bünteweg 17, D-3000 Hannover, F.R.G.

Organs of naturally infected mink were examined for the presence of Aleutian disease virus (ADV) DNA by in situ hybridization. Spleen, lymph nodes, thymus, bone marrow, kidney, liver, lung and small intestine were found to be positive for ADV to differing extents. Infected lymphoid organs showed a focal distribution of pospositive cells. Southern blot analysis of DNA extracted from infected organs revealed replicative forms of viral DNA in spleen and bone marrow samples only. These findings are consistent with a lymphotropism of ADV in vivo. Compared to the situation after experimental infection of mink these results indicate additional sites of virus replication and/or persistence of the naturally occurring disease.

Keywords: ADV, natural infection, lymphotropism

Received 12 August 1987; accepted 16 November 1987.