HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cafruny, W. A. Articles by Hovinen, D. E. Search for Related Content PubMed PubMed Citation Articles by Cafruny, W. A. Articles by Hovinen, D. E. Agricola Articles by Cafruny, W. A. Articles by Hovinen, D. E.

Infection of Mice with Lactate Dehydrogenase-elevating Virus Leads to Stimulation of Autoantibodies

Department of Microbiology, School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, U.S.A.

The development of autoimmunity was investigated in BALB/c and C58 mice infected with lactate dehydrogenase-elevating virus (LDV). Autoantibodies reactive by ELISA with syngeneic central nervous system antigens appeared early during LDV infection of both strains of mice, and were maintained for many months. Western blot analysis indicated that the LDV-induced autoantibodies reacted with a variety of different brain antigens, and mouse strain differences in the pattern of autoreactivity were observed. LDV infection of C58 and BALB/c mice also stimulated antibodies reactive with syngeneic liver-, kidney- and spleen-derived antigens, and in Swiss outbred mice heart-reactive antibodies were observed following LDV infection. These results show that autoimmunity is a feature of the deregulation of the immune system which occurs during LDV infection.

Keywords: autoantibodies, LDV, immune deregulation

Received 13 July 1987; accepted 9 November 1987.

This article has been cited by other articles:

				R. Marques, I. Antunes, U. Eksmond, J. Stoye, K. Hasenkrug, and G. Kassiotis B Lymphocyte Activation by Coinfection Prevents Immune Control of Friend Virus Infection J. Immunol., September 1, 2008; 181(5): 3432 - 3440. [Abstract] [Full Text] [PDF]

				J. E. Butler, N. Wertz, P. Weber, and K. M. Lager Porcine Reproductive and Respiratory Syndrome Virus Subverts Repertoire Development by Proliferation of Germline-Encoded B Cells of All Isotypes Bearing Hydrophobic Heavy Chain CDR3 J. Immunol., February 15, 2008; 180(4): 2347 - 2356. [Abstract] [Full Text] [PDF]

				M. Meite, S. Léonard, M. E. A. E. Idrissi, S. Izui, P. L. Masson, and J.-P. Coutelier Exacerbation of Autoantibody-Mediated Hemolytic Anemia by Viral Infection J. Virol., July 1, 2000; 74(13): 6045 - 6049. [Abstract] [Full Text]