HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rydbeck, R. Articles by Norrby, E. Search for Related Content PubMed PubMed Citation Articles by Rydbeck, R. Articles by Norrby, E. Agricola Articles by Rydbeck, R. Articles by Norrby, E.

Protective Effects of Monoclonal Antibodies against Parainfluenza Virus Type 3-induced Brain Infection in Hamsters

Department of Virology, Karolinska Institute, c/o SBL, S-105 21 Stockholm, Sweden

A collection of monoclonal antibodies (MAbs) against the haemagglutinin—neuraminidase (HN) and fusion (F) glycoproteins of parainfluenza virus type 3 (PIV3) was used for passive immunization of intracerebrally infected newborn hamsters. A significant degree of protection was obtained with MAbs against both the HN and F viral proteins, but no individual antibody conferred complete protection against disease. MAbs against different epitopes provided different degrees of protection. A MAb to the Sendai virus HN protein was found to confer protection against PIV3 brain infection.

Keywords: parainfluenza virus type 3, brain infection, monoclonal anitibodies, passive protection

Received 8 January 1988; accepted 1 February 1988.