J Gen Virol Try Microbiology Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 69 (1988), 1137-1145; DOI 10.1099/0022-1317-69-6-1137
© 1988 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Langeland, N.
Right arrow Articles by Haarr, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Langeland, N.
Right arrow Articles by Haarr, L.
Agricola
Right arrow Articles by Langeland, N.
Right arrow Articles by Haarr, L.

Interaction of Polylysine with the Cellular Receptor for Herpes Simplex Virus Type 1

Nina Langeland, Lindsey J. Moore, Holm Holmsen and Lars Haarr

Department of Biochemistry, University of Bergen, Årstadveien 19, N-5000 Bergen, Norway

We earlier reported that neomycin blocked reversibly the binding of herpes simplex virus type 1 (HSV-1) to the receptor of BHK cells, while the binding of HSV-2 to the receptor was unaffected. We could not determine whether the effect was on the virus particle, the receptor, or both. We have now tested several other cationic substances, and report that polylysine (and polyarginine) block the binding of HSV-1 to the receptor by interfering with the cellular receptor function; higher molecular weight polylysines were more potent than those of lower molecular weight. Polylysine and neomycin showed additive effects. In vitro, polylysine showed the same strong binding to the plasma membrane phosphoinositides as did neomycin. Together these data suggest that the drugs may have a common target in the cell membrane. The HSV-1 and HSV-2 virus particles were unaffected by the drugs, as was the cellular HSV-2 receptor.

Keywords: HSV-1, polylysine, receptor, cellular

Received 22 October 1987; accepted 22 February 1988.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
H. Jenssen, P. Hamill, and R. E. W. Hancock
Peptide Antimicrobial Agents
Clin. Microbiol. Rev., July 1, 2006; 19(3): 491 - 511.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
N. Cheshenko and B. C. Herold
Glycoprotein B plays a predominant role in mediating herpes simplex virus type 2 attachment and is required for entry and cell-to-cell spread
J. Gen. Virol., September 1, 2002; 83(9): 2247 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. Trybala, J.-A. Liljeqvist, B. Svennerholm, and T. Bergström
Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate
J. Virol., October 1, 2000; 74(19): 9106 - 9114.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Laquerre, R. Argnani, D. B. Anderson, S. Zucchini, R. Manservigi, and J. C. Glorioso
Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
J. Virol., July 1, 1998; 72(7): 6119 - 6130.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L Erskine and C. McCaig
Integrated interactions between chondroitin sulphate proteoglycans and weak dc electric fields regulate nerve growth cone guidance in vitro
J. Cell Sci., January 8, 1997; 110(16): 1957 - 1965.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1988 by the Society for General Microbiology.