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Reduction of Yellow Fever Virus Mouse Neurovirulence by Immunization with a Bacterially Synthesized Non-structural Protein (NS1) Fragment

Arbovirus Research Unit, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, 395 Hatfield Road, St Albans, Hertfordshire AL4 0XQ, U.K.

Part of a yellow fever virus-specified non-structural protein (NS1) was expressed in Escherichia coli as a fusion protein with -galactosidase. Immunization of mice with this partially purified NS1--galactosidase fusion protein induced yellow fever virus-specific antibodies and provided some protection against intracerebral challenge with the virus.

Keywords: yellow fever virus, fusion protein, protection

Received 9 November 1987; accepted 12 February 1988.