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Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.
The complete nucleotide sequence of a strain of hepatitis B virus, originally isolated from a naturally infected chimpanzee, has been determined. Interesting features of the sequence include the presence of an in-phase stop codon in the ‘pre-core’ region of the core antigen open reading frame. The sequence shows approximately 10% nucleotide divergence from all of the other hepatitis B virus sequences previously published and the possibility that this divergence is the result of passage through chimpanzees is discussed.
Keywords: hepatitis B virus, nucleotide sequence, divergence
Present address: Plant Biotechnology Section, Imperial Chemical Industries plc, Jealott's Hill Research Station, Bracknell RG12 6EY, U.K.
Received 10 November 1987;
accepted 24 February 1988.
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