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J Gen Virol 69 (1988), 1391-1398; DOI 10.1099/0022-1317-69-6-1391
© 1988 Society for General Microbiology
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Partial Nucleotide Sequence and Deduced Amino Acid Sequence of the Structural Proteins of Dengue Virus Type 2, New Guinea C and PUO-218 Strains

A. Gruenberg, W. S. Woo, A. Biedrzycka and Peter J. Wright

Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria 3168, Australia

The nucleotide sequence and the deduced amino acid sequence for the genes encoding the structural proteins of two strains of dengue virus type 2 (DEN-2) were determined from cDNA clones. The genes for C, prM(M) and E proteins were sequenced for the prototype DEN-2 virus, the New Guinea C strain. Also sequenced were the prM(M) and E genes of PUO-218. This strain of DEN-2 was isolated during 1980 in Bangkok and had received a limited number of laboratory passages. Comparisons of the newly determined sequences with those published for the Jamaica 1409 and Puerto Rico PR-159 (S1 vaccine candidate) strains revealed a close relationship between New Guinea C virus and both the Jamaica and PUO-218 viruses (greater than 96% similarity in nucleotides of the E gene), whereas S1 virus was the most divergent.

Keywords: dengue virus, flavivirus cDNA, structural proteins

Received 4 January 1988; accepted 7 March 1988.


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