| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
11 and 
and of Tumour Necrosis Factor on Persistent Infection with Bovine Viral Diarrhoea Virus in Vitro
1 Veterinary Infectious Disease Organization, 124 Veterinary Road, Saskatoon, Saskatchewan, Canada S7N 0W0
and2 Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W0
Non-cytopathic strains of bovine viral diarrhoea virus (BVDV) readily establish persistent infections in cells of bovine origin. The involvement of endogenous interferon (IFN) on the maintenance of the infection level, as well as the effect of exogenous IFN and tumour necrosis factor alpha (TNF-
), was studied. Although exogenous IFN suppressed the spread and replication of virus, it did not cure the infection, even when continuously present over many cell passages. TNF- alone had no antiviral effect in this system. However, both TNF- and IFN enhanced the cytopathic effect of cytopathic BVDV, and induced a BVDV-like cytopathic effect in cells infected with non-cytopathic BVDV. These data are discussed with regard to possible mechanisms of pathogenesis during fatal BVDV disease in cattle.
Keywords: interferon (BoIFN), BVDV, TNF-
Received 10 December 1987;
accepted 22 February 1988.
This article has been cited by other articles:
|
|
 |
|
  M. Schweizer, P. Matzener, G. Pfaffen, H. Stalder, and E. Peterhans "Self" and "Nonself" Manipulation of Interferon Defense during Persistent Infection: Bovine Viral Diarrhea Virus Resists Alpha/Beta Interferon without Blocking Antiviral Activity against Unrelated Viruses Replicating in Its Host Cells J. Virol., July 15, 2006; 80(14): 6926 - 6935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Horscroft, D. Bellows, I. Ansari, V. C. H. Lai, S. Dempsey, D. Liang, R. Donis, W. Zhong, and Z. Hong Establishment of a Subgenomic Replicon for Bovine Viral Diarrhea Virus in Huh-7 Cells and Modulation of Interferon-Regulated Factor 3-Mediated Antiviral Response J. Virol., March 1, 2005; 79(5): 2788 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Durantel, S. Carrouee-Durantel, N. Branza-Nichita, R. A. Dwek, and N. Zitzmann Effects of Interferon, Ribavirin, and Iminosugar Derivatives on Cells Persistently Infected with Noncytopathic Bovine Viral Diarrhea Virus Antimicrob. Agents Chemother., February 1, 2004; 48(2): 497 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Baigent, G. Zhang, M. D. Fray, H. Flick-Smith, S. Goodbourn, and J. W. McCauley Inhibition of Beta Interferon Transcription by Noncytopathogenic Bovine Viral Diarrhea Virus Is through an Interferon Regulatory Factor 3-Dependent Mechanism J. Virol., August 12, 2002; 76(18): 8979 - 8988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Charleston, M. D. Fray, S. Baigent, B. V. Carr, and W. I. Morrison Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon J. Gen. Virol., August 1, 2001; 82(8): 1893 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Swasdipan, H. Bielefeldt-Ohmann, N. Phillips, P. D. Kirkland, and M. R. McGowan Rapid Transplacental Infection with Bovine Pestivirus Following Intranasal Inoculation of Ewes in Early Pregnancy Vet. Pathol., May 1, 2001; 38(3): 275 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. DAMMANN and A. LEVITON Is some white matter damage in preterm neonates induced by a human pestivirus? Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1998; 78(3): 230F - 231. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
