J Gen Virol
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J Gen Virol 69 (1988), 1411-1414; DOI 10.1099/0022-1317-69-6-1411
© 1988 Society for General Microbiology
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Protection of Mice from Lethal Infection with Aujeszky's Disease Virus by Immunization with Purified gVI

Hiroshi Ishii, Yuichi Kobayashi, Masahiko Kuroki and Yoshikatu Kodama

Ghen Corporation, Gifu Laboratory, Sano, Gifu-City 501-11, Japan

Virus envelope glycoprotein gVI (gp50) of Aujeszky's disease virus (ADV) was purified from a Nonidet P40-solubilized lysate of ADV-infected Vero cells by immunoaffinity chromatography using a monoclonal antibody against gVI. Mice immunized by the purified gVI produced virus-neutralizing antibody and were successfully protected against subsequent challenge with ADV.

Keywords: ADV, immunity, gVI

Received 25 November 1987; accepted 3 March 1988.




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