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J Gen Virol 69 (1988), 1731-1734; DOI 10.1099/0022-1317-69-7-1731
© 1988 Society for General Microbiology
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A Recombinant Vaccinia Virus Expressing Herpes Simplex Virus Type 1 Glycoprotein B Induces Cytotoxic T Lymphocytes in Mice

Elizabeth McLaughlin-Taylor1, Dru E. Willey2, Edouard M. Cantin2, R. Eberle3,{dagger}, Bernard Moss4 and Harry Openshaw2

1 Department of Molecular Biochemistry
2 Department of Neurology
and3 Department of Pediatrics, City of Hope National Medical Center, Duarte, California 91010
and4 Laboratory for Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20205, U.S.A.

Spleen cells from BALB/c (H-2d) mice vaccinated with vgB11, a recombinant vaccinia virus which expresses glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1), lysed EMT6 (H-2d) target cells infected with vgB11 or with HSV-1 but did not lyse uninfected EMT6 cells or infected L-929 (H-2k) target cells. Unlabelled target cell competition of lysis showed that only syngeneic cells infected with vgB11 or HSV-1 inhibited lysis of radiolabelled HSV-1-infected targets. These results demonstrate that vgB11 induces H-2-restricted anti-HSV-1 cytotoxic T lymphocytes and that gB is the target antigen.

Keywords: vaccinia virus, HSV-1 glycoprotein B, cytotoxic T cells

{dagger} Present address: Department of Veterinary Parasitology, Microbiology and Public Health, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078-0353, U.S.A.

Received 22 December 1987; accepted 5 April 1988.


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