HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lewis, R. M. Articles by Jahrling, P. B. Search for Related Content PubMed PubMed Citation Articles by Lewis, R. M. Articles by Jahrling, P. B. Agricola Articles by Lewis, R. M. Articles by Jahrling, P. B.

Immune Serum Increases Arenavirus Replication in Monocytes

Medical Division and Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701, U.S.A.

The U937 monocytic cell line was used to determine whether antibodies could facilitate infection and replication of the arenaviruses, Pichinde virus (PV) and Lassa fever virus (LFV). When high dilutions of PV-immune serum were added to cultures simultaneously with PV inoculum, virus replication was dramatically (1000-fold) increased. Low dilutions of this antiserum neutralized the virus. LFV also replicated in U937 cells. The presence of LFV-specific immune serum in the growth medium increased the viral titre as much as 10000-fold. Addition of heat-aggregated IgG partially inhibited antibody-mediated enhancement, probably by inhibiting the binding of immune complexes to the monocytic cells.

Keywords: LFV, PV, arenavirus

Received 27 October 1987; accepted 20 April 1988.

This article has been cited by other articles:

				S. Baize, J. Kaplon, C. Faure, D. Pannetier, M.-C. Georges-Courbot, and V. Deubel Lassa Virus Infection of Human Dendritic Cells and Macrophages Is Productive but Fails to Activate Cells J. Immunol., March 1, 2004; 172(5): 2861 - 2869. [Abstract] [Full Text] [PDF]

				T. Joseph, M. T. Kibenge, and F. S. B. Kibenge Antibody-mediated growth of infectious salmon anaemia virus in macrophage-like fish cell lines J. Gen. Virol., July 1, 2003; 84(7): 1701 - 1710. [Abstract] [Full Text] [PDF]

				P. Seiler, U. Kalinke, T. Rulicke, E. M. Bucher, C. Bose, R. M. Zinkernagel, and H. Hengartner Enhanced Virus Clearance by Early Inducible Lymphocytic Choriomeningitis Virus-Neutralizing Antibodies in Immunoglobulin-Transgenic Mice J. Virol., March 1, 1998; 72(3): 2253 - 2258. [Abstract] [Full Text] [PDF]