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J Gen Virol 69 (1988), 1749-1751; DOI 10.1099/0022-1317-69-7-1749
© 1988 Society for General Microbiology
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Antiviral Activity of Flavones and Potentiation by Ascorbate

Raf Vrijsen, Ludwig Everaert and Albert Boeyé

Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium

We compared the anti-poliovirus activities of three flavones, quercetin, luteolin and 3-methylquercetin, which differ only at ring position 3. 3-Methylquercetin was the most potent compound. Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate. The antiviral activity of luteolin was comparable to that of ascorbate-stabilized quercetin.

Keywords: flavones, ascorbate, poliovirus

Received 11 March 1988; accepted 22 March 1988.


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