J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 69 (1988), 1921-1929; DOI 10.1099/0022-1317-69-8-1921
© 1988 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Deubel, V.
Right arrow Articles by Trent, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Deubel, V.
Right arrow Articles by Trent, D. W.
Agricola
Right arrow Articles by Deubel, V.
Right arrow Articles by Trent, D. W.

Dengue 2 Virus Envelope Protein Expressed by a Recombinant Vaccinia Virus Fails to Protect Monkeys against Dengue

Vincent Deubel1,{dagger}, Richard M. Kinney1, Joseph J. Esposito2, C. Bruce Cropp1, A. Vance Vorndam1, Thomas P. Monath1 and Dennis W. Trent1

1 Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522
and2 Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Road, Atlanta, Georgia 30333, U.S.A.

A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

Keywords: dengue, vaccinia virus recombinant, flavivirus

{dagger} Present address: Department of Virology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France.

Received 15 January 1988; accepted 5 May 1988.


This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
K. Raviprakash, K. R. Porter, T. J. Kochel, D. Ewing, M. Simmons, I. Phillips, G. S. Murphy, W. R. Weiss, and C. G. Hayes
Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques
J. Gen. Virol., July 1, 2000; 81(7): 1659 - 1667.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
A. J. Johnson and J. T. Roehrig
New Mouse Model for Dengue Virus Vaccine Testing
J. Virol., January 1, 1999; 73(1): 783 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. E. Stocks and M. Lobigs
Signal Peptidase Cleavage at the Flavivirus C-prM Junction: Dependence on the Viral NS2B-3 Protease for Efficient Processing Requires Determinants in C, the Signal Peptide, and prM
J. Virol., March 1, 1998; 72(3): 2141 - 2149.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1988 by the Society for General Microbiology.