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J Gen Virol 69 (1988), 1979-1985; DOI 10.1099/0022-1317-69-8-1979
© 1988 Society for General Microbiology
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Antiviral Activity of Recombinant Rat Interferon Gamma in Immunologically Impaired and Immunosuppressed Rats

Virgil E. C. J. Schijns1, Ton H. Borman2, Huub Schellekens2 and Marian C. Horzinek1

1 Institute of Virology, Veterinary Faculty, State University Utrecht, Yalelaan 1, 3508 TD Utrecht
and2 Primate Center TNO, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands

Treatment of Wag/Rij rats with recombinant rat interferon gamma (rRIF-{gamma}) resulted in complete protection against a lethal pseudorabies virus (PRV) infection. To investigate whether the protection resulted from direct inhibition of virus replication or from a stimulation of immune mechanisms, we tested rRIF-{gamma} activity in naturally immunocompromised and artificially immunosuppressed rats. The antiviral effect of rRIF-{gamma} was not abolished in silica- and carrageenan-treated, phagocyte-depleted rats. Immunologically immature newborn and T cell-deficient nude rats were also protected under a regime of rRIF-{gamma} treatment as well as whole body gamma-irradiated rats. Sera of the protected rats were devoid of PRV-neutralizing antibodies. Our results indicate that the protective activity of rRIF-{gamma} is based on direct inhibition of virus replication; stimulation of the immune system is not required but may be responsible for protection upon challenge several weeks after infection.

Keywords: interferon (rat IFN-{gamma}), PRV infection, antiviral activity

Received 3 December 1987; accepted 30 March 1988.




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