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Immunological Conservation between Epstein-Barr Virus and Herpes Simplex Virus

B. Wendy Snowden^2,

¹ Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
² MRC Herpesvirus Research Group, Department of Microbiology, University of Leeds, Leeds LS2 9JT
and³ Department of Biochemical Virology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K.

We have analysed Epstein-Barr virus (EBV)- and herpes simplex virus (HSV)-infected cells for evidence of antigenic conservation of virus-coded proteins. Immunofluorescence and Western blot analyses of EBV-transformed cell lines demonstrated the presence of proteins that are antigenically related to the HSV alkaline DNase, infected cell-specific protein 34/35, glycoprotein B, thymidine kinase and the major DNA-binding protein. These proteins were characterized on the basis of M_r and possible kinetic class.

Keywords: EBV, HSV, antigenic conservation

Present address: Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92717, U.S.A.

Received 9 February 1988; accepted 19 May 1988.