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Neutralization and Sensitization of Lactate Dehydrogenase-elevating Virus with Monoclonal Antibodies

^* Unit of Experimental Medicine, Université Catholique de Louvain and International Institute of Cellular and Molecular Pathology, Avenue Hippocrate 75, B-1200 Bruxelles, Belgium
and Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, U.S.A.
and¹ Ludwig Institute for Cancer Research, Bruxelles, Belgium

Monoclonal antibodies directed against VP3, the envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV), were found to neutralize a large proportion of the virus population. This effect of monoclonal anti-VP3 antibodies was significantly increased by a murine monoclonal rheumatoid factor, indicating that the same antiviral antibodies can either neutralize or sensitize different fractions of the virus. This observation could be explained by heterogeneity in LDV particles, resulting in diverse responses to antibodies and therefore to the persistence of the virus in vivo.

Keywords: LDV, rheumatoid factor, monoclonal antibodies

Received 4 January 1988; accepted 26 April 1988.

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