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1 Department of Virology, U.S. Army Medical Component, Armed Forces Research Institute of the Medical Sciences, 315/6 Rajavithi Road, Bangkok 10400, Thailand
and2 Department of Medicine, Rochester General Hospital and the University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, U.S.A.
Non-neutralizing, serotype-specific anti-NS1 monoclonal antibodies partially protected passively immunized mice from lethal dengue 2 virus intracerebral challenge. There was no apparent correlation between complement-fixing activity and protective capacity among individual anti-NS1 monoclonal antibodies. Immunization with specific combinations of non-protective or partially protective antibodies resulted in prolonged survival or reduced mortality. Solid protection, equal to that achieved after immunization with neutralizing polyclonal antibody, was achieved only with an antibody pair which individually fixed complement to high titre with homologous virus. Some groups of mice had increased morbidity after immunization with combinations of protective monoclonal antibodies that bind to overlapping epitopes. These results may affect the design of recombinant dengue vaccines which may require the inclusion of serotype-specific antigenic domains.
Keywords: dengue 2 virus, flaviviruses, passive protection
Present address: Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100, U.S.A.
Received 16 December 1987;
accepted 25 March 1988.
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