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Immunization against Foot-and-Mouth Disease with Synthetic Peptides Representing the C-terminal Region of VP1

¹ Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, U.K.
and² Eli Lilly Research Laboratories, Indianapolis, Indiana 46285, U.S.A.

Foot-and-mouth disease virus challenge experiments in guinea-pigs and immunoassays with a range of peptides equivalent to either or both of the sequences 141 to 158 and 200 to 213 of VP1 showed the most effective structure, in terms of protection, to be one in which both ‘sites’ were present with a minimum of additional amino acids. An 80 residue peptide comprising amino acids 134 to 213 was considerably less effective than 40 or 45 residue peptides. The major site for the induction of protection was deduced to be in the region 141 to 158. Thus, protection with the 40 or 45 residue peptide did not appear to be due to the presence of antibody directed solely to the 200 to 213 sequence. Finally, induction of antibody to the latter site appeared to be dependent on both the size of the peptide and the disposition of ‘sites’ within it.

Keywords: FMDV, immunization, peptide vaccines

Received 30 November 1987; accepted 7 June 1988.