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Electron Microscopic Study of Tissue Cultures Infected with Simian Haemorrhagic Fever Virus

Nicola Tauraso

The^_* Department of Epidemiology and Public Health and the
Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut, and the
Laboratory of Virology and Rickettsiology, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland

The morphology and development of simian haemorrhagic fever virus was studied in tissue cultures infected with low multiplicities of virus. Early cytoplasmic lesions which were observed 24 hr after infection consisted of increased concentrations of polysomes and small vesicles 100 nm. in diameter filled with densely staining fibrillar material. As the lesions progressed, thickened membraneous structures developed at the periphery of the vesicles. The membranes appeared to lengthen and thicken by a process of end-to-end and side-to-side fusion. Serial sections demonstrated that the fused, thickened structures were lamellae. Their role in the morphogenesis of simian haemorrhagic fever virus is not presently known.

Spherical virus particles measuring 40 to 45 nm. in diameter appeared in cells by 72 hr after infection. Infected cells contained vacuoles which enclosed accumulations of enveloped spherical particles. Some particles appeared to be budding into vacuoles.

Received 16 October 1969; accepted 29 December 1969.

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