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Characterization of a New Temperature-sensitive and Avirulent Mutant of the Rabies Virus

Laboratoire de Génétique des Virus, CNRS, 91198 Gif sur Yvette Cédex, France

A temperature-sensitive (ts) mutant, tsG1, has been isolated from the CVS (Challenge Virus Standard) strain of rabies virus. The ts mutation affects the glycoprotein (G protein); it consists of an amino acid substitution (leucine to phenylalanine) at position 132. tsG1 exhibits a slightly reduced pathogenicity when administered via the intracerebral route and complete avirulence after intramuscular inoculation, associated with a very high protective power for adult mice. The ts mutation does not seem to block the transport of the G protein to the plasma membrane at the non-permissive temperature (39.6 °C). It abolishes the c.p.e. of the virus in cell cultures.

Keywords: rabies virus, ts mutant, avirulent mutant

Received 31 May 1988; accepted 23 September 1988.

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