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Restricted Expression of Viral Glycoprotein in Vesicular Stomatitis Virus-infected Drosophila melanogaster Cells

Laboratoire de Génétique des Virus, CNRS, 91198 Gif sur Yvette Cédex, France

Vesicular stomatitis virus (VSV) establishes a non-cytopathic persistent infection in Drosophila melanogaster cells. The synthesis of the viral glycoprotein G was specifically inhibited during a post-transcriptional step, whereas the synthesis and turnover of its mRNA were not modified compared with the other viral mRNAs. Another viral glycoprotein, migrating slightly faster than G protein on an SDS-polyacrylamide gel, was detected in infected Drosophila cells. This protein showed most of the characteristics of the intracellular Gs protein found in infected vertebrate cells. The amounts of G protein integrated into mature virions and of soluble Gs protein secreted into the culture medium were reduced greatly during VSV infection in Drosophila cells.

Keywords: VSV, glycoprotein, persistent infection

Received 18 September 1987; accepted 7 October 1988.