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Characterization of Antigenic Variants of Tick-borne Encephalitis Virus Selected with Neutralizing Monoclonal Antibodies

Institute of Virology, University of Vienna, Kinderspitalgasse 15, A-1095 Vienna, Austria

Antigenic variants of tick-borne encephalitis virus were selected by the use of six neutralizing monoclonal antibodies (MAbs), each defining a different epitope of the envelope glycoprotein E. These variants were characterized with respect to antigenic changes by analysing the binding of each of 18 precisely mapped MAbs in ELISA and haemagglutination inhibition tests. The results yielded information about interrelations between epitopes exceeding that obtained previously from competitive binding studies. In addition, variants were tested for their specific haemagglutination activities, which revealed a significant reduction of this functional activity in one of the variants.

Keywords: TBE virus, MAbs, neutralization

Received 27 June 1988; accepted 3 October 1988.

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