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1 Division of Vector-Borne Viral Diseases, Center for Infectious Disease, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522-2087
2 U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011
3 Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, Connecticut 06510, U.S.A.
4 Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.
5 Department of Microbiology, Monash University Medical School, Clayton, Victoria 3168, Australia
and6 U.S. Army Medical Material Development Activity, Frederick, Maryland 21701-5009, U.S.A.
The recently established virus family Flaviviridae contains at least 68 recognized members. Sixty-six of these viruses were tested by cross-neutralization in cell cultures. Flaviviruses were separated into eight complexes [tick-borne encephalitis (12 viruses), Rio Bravo (six), Japanese encephalitis (10), Tyuleniy (three), Ntaya (five), Uganda S (four), dengue (four) and Modoc (five)] containing 49 viruses; 17 other viruses were not sufficiently related to warrant inclusion in any of these complexes.
Keywords: flaviviruses, neutralization, antigenic relationships
Received 28 June 1988;
accepted 4 October 1988.
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