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J Gen Virol 70 (1989), 2555-2562; DOI 10.1099/0022-1317-70-10-2555
© 1989 Society for General Microbiology
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Localization of Human Papillomavirus Type 16 DNA Using the Polymerase Chain Reaction in the Cervix Uteri of Women with Cervical Intraepithelial Neoplasia

Marion T. E. Cornelissen1, Jan G. van den Tweel2, Arie P. H. B. Struyk3, Maarten F. Jebbink1, Maarten Briët3, Jan van der Noordaa1 and Jan Ter Schegget1

1 Department of Medical Microbiology
2 Department of Pathology
and3 Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

The localization of human papillomavirus type 16 (HPV-16) DNA throughout the cervix uteri of women with cervical intraepithelial neoplasia (CIN) was studied by utilizing the polymerase chain reaction technique directly on histologically defined sections of paraffin-embedded cervical tissue obtained by conizations. HPV-16 DNA was detected only in the sections that contained CIN lesions and/or koilocytes. No HPV-16 DNA was detected in sections that contained only normal epithelium. This is in accordance with HPV-16 playing a role in the development of CIN lesions.

Keywords: PCR, papillomavirus, human type 16, cervix uteri

Received 14 March 1989; accepted 12 June 1989.


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[Abstract] [Full Text] [PDF]


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