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J Gen Virol 70 (1989), 3291-3296; DOI 10.1099/0022-1317-70-12-3291
© 1989 Society for General Microbiology
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Secretory Immunoglobulin A Antibody Response Is Conserved in Aged Mice following Oral Immunization with Influenza Virus Vaccine

Ker-Sang Chen and Gerald V. Quinnan, Jr

Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, U.S.A.

Parenteral immunization of BALB/c mice at 3 months of age with inactivated influenza virus vaccine elicited a haemagglutinin (HA)-specific serum IgG antibody response. The magnitude of this response declined with advancing age at the time of vaccination. By contrast, HA-specific IgA and IgG antibody levels observed in lung lavage fluids of mice immunized at 1 and 2 years of age were comparable to those of 5 month old mice when inactivated influenza virus vaccine was administered intragastrically. The secretory immune response was not fully developed in the first 3 weeks of life. However, the HA-specific IgA and IgG responses to oral vaccination in sera were reduced in 1 or 2 year old mice when compared to 5 month old mice. These data demonstrated the preservation of the virus-specific secretory IgA response in the pulmonary fluids of aged mice after oral vaccination with inactivated influenza virus vaccine. An age-dependent difference of systemic and mucosal immunity was evident in orally immunized mice.

Keywords: mucosal immunity, influenza virus, ageing, oral vaccination

Received 6 June 1989; accepted 27 July 1989.




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