HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Frugulhetti, I. C. P. P. Articles by Rebello, M. A. Search for Related Content PubMed PubMed Citation Articles by Frugulhetti, I. C. P. P. Articles by Rebello, M. A. Agricola Articles by Frugulhetti, I. C. P. P. Articles by Rebello, M. A.

Na⁺ and K⁺ Concentration and Regulation of Protein Synthesis in L-A9 and Aedes albopictus Cells Infected with Marituba Virus (Bunyaviridae)

I. C. P. P. Frugulhetti

Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro-Centro de Ciências da Saúde, Cidade Universitária, 21941 Rio de Janeiro RJ, Brasil

Infection of L-A9 cells with Marituba virus produces a severe inhibition of protein synthesis. This inhibition is temporally correlated with an increase in the intracellular Na⁺ concentration and a decrease in the intracellular K⁺ concentration. However in Marituba virus-infected Aedes albopictus cells the intracellular level of Na⁺ and K⁺ ions and protein synthesis remained unaltered. Incubation of both cell types at high NaCl concentration facilitated the translation of viral RNA whereas the cellular protein synthesis was inhibited. Using a hypotonic medium, the opposite was found. Results are discussed in terms of a possible involvement of these ions in the viral translational process.

Keywords: MTBV, cations, protein synthesis

Present address: Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Brasil.

Received 17 May 1989; accepted 30 August 1989.

This article has been cited by other articles:

				G. Blakqori, I. van Knippenberg, and R. M. Elliott Bunyamwera Orthobunyavirus S-Segment Untranslated Regions Mediate Poly(A) Tail-Independent Translation J. Virol., April 15, 2009; 83(8): 3637 - 3646. [Abstract] [Full Text] [PDF]

				A. Bridgen, F. Weber, J. K. Fazakerley, and R. M. Elliott Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis PNAS, January 16, 2001; 98(2): 664 - 669. [Abstract] [Full Text] [PDF]