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Na⁺ and K⁺ Concentration and Regulation of Protein Synthesis in L-A9 and Aedes albopictus Cells Infected with Marituba Virus (Bunyaviridae)

I. C. P. P. Frugulhetti

Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro-Centro de Ciências da Saúde, Cidade Universitária, 21941 Rio de Janeiro RJ, Brasil

Infection of L-A9 cells with Marituba virus produces a severe inhibition of protein synthesis. This inhibition is temporally correlated with an increase in the intracellular Na⁺ concentration and a decrease in the intracellular K⁺ concentration. However in Marituba virus-infected Aedes albopictus cells the intracellular level of Na⁺ and K⁺ ions and protein synthesis remained unaltered. Incubation of both cell types at high NaCl concentration facilitated the translation of viral RNA whereas the cellular protein synthesis was inhibited. Using a hypotonic medium, the opposite was found. Results are discussed in terms of a possible involvement of these ions in the viral translational process.

Keywords: MTBV, cations, protein synthesis

Present address: Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Brasil.

Received 17 May 1989; accepted 30 August 1989.

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