HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Collett, M. S. Articles by Horzinek, M. C. Search for Related Content PubMed PubMed Citation Articles by Collett, M. S. Articles by Horzinek, M. C. Agricola Articles by Collett, M. S. Articles by Horzinek, M. C.

Recent Advances in Pestivirus Research

Marc S. Collett^1,

¹ Molecular Genetics Inc., 10320 Bren Road East, Minnetonka, Minnesota 55343, U.S.A.
² Institute of Virology, Veterinary School, Bünteweg 17, D-3000, Hannover 71, F.R.G.
and³ Department of Virology, Institute of Infectious Diseases and Immunology, Veterinary Faculty, State University, Yalelaan 1, 3508 TD Utrecht, The Netherlands

Introduction. The term ‘pestivirus’ was coined in 1973 to group together two antigenically related enveloped RNA viruses: hog cholera virus (HCV) and bovine viral diarrhoea virus (BVDV; Horzinek, 1973). A third animal pathogen, the border disease virus (BDV) of sheep, was found later to be a close relative of BVDV. Pestiviruses are among the smallest enveloped animal RNA viruses (about 40 nm in diameter) and possess a nucleocapsid of non-helical, probably icosahedral symmetry (Horzinek et al., 1967); they share these traits with the numerous flaviviruses, of which the arthropod-borne yellow fever virus is the prototype. The pestiviruses are not arthropod-borne and currently hold generic status in the family Togaviridae. Previously, flaviviruses also held generic status in this family. However, when details of flavivirus molecular structure, replication strategy and gene sequence became known in the early 1980s, the Togaviridae Study Group recognized the fundamental differences and proposed the creation of the new family Flaviviridae with Flavivirus as the only genus (Westaway et al., 1985).

Keywords: HCV, BVDV, pestivirus

Present address: Molecular Vaccines Inc., 19 Firstfield Road, Gaithersburg, Maryland 20878, U.S.A.

This article has been cited by other articles:

				E. Grego, F. Uslenghi, M. Strasser, C. Luzzago, M. Frigerio, S. Peletto, and S. Rosati Development and application of an enzyme-linked immunosorbent assay for detection of bovine viral diarrhea antibody based on Erns glycoprotein expressed in a baculovirus system J Vet Diagn Invest, January 1, 2007; 19(1): 21 - 27. [Abstract] [Full Text] [PDF]

				A.-R. N. ZEKRI, A. A. BAHNASSY, S. M. SHAARAWY, O. A. MANSOUR, M. A. MADUAR, H. M. KHALED, and O. EL-AHMADI Hepatitis C virus genotyping in relation to neu-oncoprotein overexpression and the development of hepatocellular carcinoma J. Med. Microbiol., January 1, 2000; 49(1): 89 - 95. [Abstract] [Full Text] [PDF]

				N. Tautz, T. Harada, A. Kaiser, G. Rinck, S.-E. Behrens, and H.-J. Thiel Establishment and Characterization of Cytopathogenic and Noncytopathogenic Pestivirus Replicons J. Virol., November 1, 1999; 73(11): 9422 - 9432. [Abstract] [Full Text] [PDF]