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The Characterization of Neutralizing and Non-neutralizing Monoclonal Antibodies against Equid Herpesvirus Type 1

Department of Infectious Diseases, Animal Health Trust, Lanwades Park, Kennett, Newmarket, Suffolk CB8 7PN, U.K.

Seven monoclonal antibodies (MAbs) were produced which recognized equid herpesvirus type 1 (EHV-1). Three MAbs neutralized the subtype 1 virus (strain Army 183) in the presence of complement, but did not neutralize the subtype 2 virus (strain MD). All three MAbs immunoprecipitated an M_r 83K glycoprotein from a detergent-solubilized virion envelope preparation of the subtype 1 virus. The target antigens of the four non-neutralizing MAbs (6F11, 2A4, 1F10 and 8D9) were identified by immunoblotting against purified EHV-1 virions and had respective apparent M_r values of > 205K, > 205K, 97K and 13K.

Keywords: EHV-1, MAbs, neutralizing and non-neutralizing

Received 6 May 1988; accepted 13 October 1988.

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